A New “CRISPR Pill” Makes Bacteria Destroy Its Own DNA


An innovative study in the University of Wisconsin-Madison could soon put an end to drug-resistant bacteria by using an edible version of CRISPR. This probiotic could target specific bacteria, making it more effective than antibiotics.

TARGETED AND EDIBLE

As antibiotic resistance continues to grow, scientists are desperately trying to figure out how to best fight bacterium like Clostridium difficile, which can cause fatal infections in hospitals and nursing homes. C. difficile has been ranked by the U.S. Centers for Disease Control and Prevention (CDC) as a top drug-resistant threat responsible for about 15,000 deaths per year. Several means are being explored to counter the pandemic, the most recent coming from a project funded by the National Institute of Health.

Clostridium difficile. Credit: CDC
The proposed solution uses CRISPR, the world’s most precise and efficient gene editing technology currently available. Jan-Peter van Pijkeren, a food scientist from the University of Wisconsin-Madison, is creating a probiotic cocktail that patients can swallow as a liquid or pill.

The cocktail of bacteria will include a bacteriophage – a virus that infects bacteria – capable of carrying a customized, false, CRISPR message to C. difficile. This message would cause C. difficile to make lethal cuts to its own DNA.

BETTER THAN ANTIBIOTICS

Currently, this probiotic is still in its early stages, according to van Pijkeren, and is yet to be tested on animals. Luckily, similar studies have proven the effectiveness of bacteriophage-delivered CRISPR in killing bacteria. However, researchers still have some concerns.

“The downside of antibiotics is they are a sledgehammer that depletes and destroys the gut microbial community,” van Pijkeren said to the University of Wisconsin-Madison. “You want to instead use a scalpel in order to specifically eradicate the microbe of interest.”

CRISPR is ideal for this use because such drugs would be very specific to the user. They could kill a single species of germ while leaving good bacterial untouched. In contract, regular antibiotics kill off both good and bad bacteria, leading to resistance. If proven successful, CRISPR could become, not just the world’s most effective gene editing tool, but also the best bacteria-killing technology available. While this is a long way off, it still gives hope to thousands.

“As long as we house patients together in a hospital or in a nursing home and we give a lot of them antibiotics we’re going to have a problem with C. difficile,” says Herbert DuPont, director of the Center for Infectious Diseases at the University of Texas to MIT Technology Review.

References: 
New on MIT Technology Review,
University of Wisconsin-Madison

futurism.com
Name

Admin Says,727,Break News,10324,History,414,Humor-Σάτυρα-Κεντρίσματα,907,Interesting,1691,Movies,13,Nature-Travel,307,Reportage-Exclusive,69,Sience - Technology,496,Social Media,133,Sports,702,Video,29,Άρθρα,435,Αστυνομιία-Έγκλημα,438,Βιβλία-Εκδόσεις,61,Γιώργος Φάκος,114,Διηγήματα,49,Ειδήσεις,9271,Ηealth - Μedicine,880,Καταγγελίες,210,Λογοτεχνία,8,Λογοτεχνία.,3,Μαγειρική-συνταγές,396,Μουσική,146,Νίκος Ράμμος,225,Ομογένεια,780,Συγγραφείς,121,
ltr
item
Greek Canadian Online Media: A New “CRISPR Pill” Makes Bacteria Destroy Its Own DNA
A New “CRISPR Pill” Makes Bacteria Destroy Its Own DNA
https://3.bp.blogspot.com/-PnLH0Dyz0ts/WP2HVjavYiI/AAAAAAAAa50/5cv5MzZi1aw63iPpfNY4XGqvqkpxMeyEQCLcB/s640/2017-04-24_1-01-08.png
https://3.bp.blogspot.com/-PnLH0Dyz0ts/WP2HVjavYiI/AAAAAAAAa50/5cv5MzZi1aw63iPpfNY4XGqvqkpxMeyEQCLcB/s72-c/2017-04-24_1-01-08.png
Greek Canadian Online Media
http://www.tgbnews.com/2017/04/a-new-crispr-pill-makes-bacteria.html
http://www.tgbnews.com/
http://www.tgbnews.com/
http://www.tgbnews.com/2017/04/a-new-crispr-pill-makes-bacteria.html
true
2038196663235419812
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS CONTENT IS PREMIUM Please share to unlock Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy